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Impact of Collagen Peptide Supplementation in Combination with Long-Term Physical Training on Strength, Musculotendinous Remodeling, Functional Recovery, and Body Composition in Healthy Adults: A Systematic Review with Meta-analysis

Kevin Bischof, Anna Maria Moitzi
Sports Medicine 2024 54(11):2865–2888

Bibliography

PubMed
PMID 39060741
PubMed Central
PMC11561013
Funding
Open-access funding was provided by the University of Vienna. The authors reported no external funding for preparation and writing of the review.
Competing interests
The authors declared no commercial or financial relationships that could be construed as a potential conflict of interest.

Study snapshot

DesignSystematic review and random-effects meta-analysis of training/supplementation RCTs
ModelPhysically active and sedentary adults undergoing resistance training, mostly men
Sample19 RCTs; 768 participants (613 men, 155 women)
InterventionCollagen peptides typically 3–30 g/day, often with exercise and sometimes vitamin C
DurationMost studies ≥8 weeks
EndpointsFat-free mass; Tendon morphology; Muscle architecture; Strength; Recovery

What the study showed, in plain terms

Long-term collagen plus training favored some body-composition, tendon and strength measures versus controls; effects were heterogeneous and cannot be assumed to occur without exercise.

Key findings

Pooled fat-free mass SMD 0.48; tendon morphology SMD 0.67; muscle architecture SMD 0.39; maximum strength SMD 0.19.

What this study can and cannot tell us

Most participants male; doses, training and vitamin C co-interventions varied; several small industry-specific formulation trials; cannot assume gains reflect myofibrillar protein synthesis.

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