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A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder

Jay D Amsterdam, Yimei Li, Irene Soeller, Kenneth Rockwell, Jun James Mao, Justine Shults
Journal of Clinical Psychopharmacology 2009 29(4):378-382

Bibliography

PubMed
PMID 19593179
PubMed Central
PMC3600416

Study snapshot

DesignRandomized double-blind placebo-controlled trial
ModelAdults with mild-to-moderate generalized anxiety disorder
Sample
InterventionOral Matricaria recutita chamomile extract versus placebo
Duration8 weeks
EndpointsHamilton Anxiety Rating Scale; Clinical response; Safety and tolerability

What the study showed, in plain terms

This placebo-controlled trial tested chamomile extract for generalized anxiety disorder. It is relevant to apigenin because chamomile contains apigenin, but it did not test isolated apigenin.

Key findings

Chamomile produced a modest anxiolytic signal versus placebo in this small trial and was generally well tolerated.

What this study can and cannot tell us

The sample was modest and the intervention was a multi-compound botanical extract. The result cannot establish that apigenin itself treats GAD.

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