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Oral Hyaluronic Acid Supplement: Efficacy in Skin Hydration, Elasticity, and Wrinkle Depth Reduction

Pouya Amin, Ali Sarabi, Sarah Choe, Sacha Scott, Susie Suh, Natasha A Mesinkovska
Journal of Drugs in Dermatology 2025 24(9):910-919

Bibliography

PubMed
PMID 40911749
DOI
10.36849/jdd.8542

Study snapshot

DesignSystematic literature search and meta-analysis of randomized controlled trials
ModelAdults enrolled in placebo-controlled oral hyaluronic acid skin trials
Sample7 randomized controlled trials
InterventionOral hyaluronic acid supplementation versus placebo; doses and formulations varied across trials
DurationVaried across included RCTs
EndpointsSkin hydration; Skin elasticity; Wrinkle depth; Skin firmness; Wrinkle volume; Transepidermal water loss

What the study showed, in plain terms

This 2025 meta-analysis pooled seven randomized controlled trials of oral hyaluronic acid for skin outcomes.

Pooled results favored oral HA for skin hydration, elasticity and wrinkle depth. Effects on firmness, wrinkle volume and transepidermal water loss were not statistically significant in the meta-analysis.

The synthesis strengthens the case that oral HA can affect measurable skin outcomes, while also highlighting the small samples and heterogeneity of the underlying trials.

Key findings

  • Seven randomized controlled trials were included.
  • Pooled effects were statistically significant for skin hydration, elasticity and wrinkle depth.
  • Pooled effects for firmness, wrinkle volume and transepidermal water loss did not reach statistical significance.

What this study can and cannot tell us

  • Only seven RCTs were available, many with small sample sizes.
  • Included trials used different doses, molecular weights, populations and measurement methods.
  • The pooled evidence is therefore supportive but not a definitive dose- or formulation-specific estimate.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology