Tier 3 — preclinical
A single-blind, parallel trial of l-hydroxyproline in healthy adult subjects
Urolithiasis
2015
43(3):289–292
Bibliography
- PubMed
- PMID 25827754
- PubMed Central
- PMC4436679
- Funding
- Kyowa Hakko Bio Co., Ltd.
- Competing interests
- Three authors were company employees and one was a consultant.
Study snapshot
| Design | Single-blind four-arm parallel dose-ranging human trial |
|---|---|
| Model | Healthy adults without kidney disease or known kidney stones |
| Sample | 40 recruited; 37 completed |
| Intervention | 0, 500, 1000 or 2000 mg/day isolated l-hydroxyproline |
| Duration | 12 weeks plus 4-week washout |
| Endpoints | Urinary oxalate; Urinalysis; Safety labs |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
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