Evidence library 17 analyses
Research on resveratrol, sirtuin biology and cardiometabolic outcomes, with dosing, bioavailability and safety analysis.
Complete library
Browse every published guide, review and evidence update in this topic.
Does resveratrol activate SIRT1 in humans? A 2025 meta-analysis of randomized trials found no significant overall increase in SIRT1 gene expression, protein expression or circulating SIRT1. Here is...
Resveratrol became famous as a longevity molecule after striking animal and sirtuin research. But does it extend human lifespan? Here is the 2026 evidence from mouse studies, human...
Resveratrol is not simply “poorly absorbed.” Human studies show substantial absorption followed by rapid metabolism, leaving little unchanged resveratrol in circulation. Here is what formulations, dose and food...
Resveratrol can alter human drug-metabolizing enzymes. This guide covers CYP3A4, CYP2D6, CYP2C9, CYP1A2 and CYP2E1 evidence, carbamazepine data, blood-thinner concerns and when to ask a clinician.
Resveratrol is generally tolerated in short human trials, but high doses can cause gastrointestinal effects and medication interactions matter. Here is the safety evidence.
There is no universal resveratrol dosage. This evidence-based guide maps doses used in human trials, explains why higher is not necessarily better, and separates research doses from practical...
Resveratrol benefits ranked by strength of human evidence, from cardiometabolic and inflammatory outcomes to cognition, osteoarthritis and longevity claims.
An evidence-first 2026 guide to resveratrol supplements: human benefits, dosage, safety, bioavailability, longevity claims, SIRT1 and where the science remains uncertain.
