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TEAS, DHEA, CoQ10, and GH for poor ovarian response undergoing IVF-ET: a systematic review and network meta-analysis

Fengya Zhu, Shao Yin, Bin Yang, Siyun Li, Xia Feng, Tianyu Wang, Deya Che
Reproductive Biology and Endocrinology 2023 21(1):64

Bibliography

PubMed
PMID 37464357
PubMed Central
PMC10355041
DOI
10.1186/s12958-023-01119-0
Funding
Not specified in the accessible abstract.
Competing interests
The authors declared no competing interests.

Study snapshot

DesignSystematic review and network meta-analysis of randomized controlled trials
ModelHuman; women with poor ovarian response undergoing IVF-ET
Sample2323
InterventionNetwork comparison of CoQ10, DHEA, growth hormone, transcutaneous electrical acupoint stimulation, and control strategies.
DurationVaried across included trials.
EndpointsClinical pregnancy; Live birth; Retrieved oocytes; Mature oocytes; Cycle outcomes

What the study showed, in plain terms

This network meta-analysis compared several pretreatment strategies for women with poor ovarian response undergoing IVF. CoQ10 was associated with higher clinical pregnancy and live-birth odds versus control in the network analysis, but these estimates combine direct and indirect evidence and should not be treated as definitive proof that CoQ10 improves live birth.

Key findings

Across 16 randomized trials involving 2,323 women, the network analysis estimated higher clinical pregnancy odds with CoQ10 versus control (OR 2.22, 95% CI 1.05-4.71) and higher live-birth odds (OR 2.36, 95% CI 1.07-5.38).

What this study can and cannot tell us

Network meta-analysis depends on assumptions that allow indirect comparisons across different trials, populations, and treatment protocols. The CoQ10-specific direct evidence was smaller than the full 16-trial network, and uncertainty remains around treatment protocols and robustness of live-birth estimates.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology