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Efficacy of combined undenatured type II collagen and hydrolysed collagen supplementation in knee osteoarthritis: a randomised controlled trial

Varah Yuenyongviwat, Chirathit Anusitviwat, Pakjai Tuntarattanapong, Theerawit Hongnaparak, Khanin Iamthanaporn
Scientific Reports 2025 15:32313

Bibliography

PubMed
PMID 40897777
PubMed Central
PMC12405528
DOI
10.1038/s41598-025-17505-0
Funding
Funding was reported from the Medical Council of Thailand / Police General Dr Jongjate Aojanepong Foundation as described in the article.
Competing interests
Authors declared no competing interests.

Study snapshot

DesignDouble-blind randomized placebo-controlled OA trial
ModelPatients with knee osteoarthritis
Sample68 adults with knee osteoarthritis
InterventionCombined hydrolysed collagen plus undenatured type II collagen tablet versus placebo
Duration12 weeks
EndpointsPain ratings; KOOS function; Rescue medication; Patient satisfaction; Adverse events

What the study showed, in plain terms

A small independent 2025 RCT found no advantage of a combined hydrolysed plus undenatured type II collagen supplement over placebo on knee OA symptoms or function at 12 weeks.

Key findings

Both groups improved, but no significant between-group differences in pain, KOOS, rescue drugs or satisfaction; no adverse events reported.

What this study can and cannot tell us

Combination supplement, not isolated hydrolysed collagen; 68 people over 12 weeks. Does not disprove outcomes from other preparations or long-term trials.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology