Tier 3 — preclinical

Improvement of dry skin by a food containing hyaluronic acids derived from microbial fermentation

T Yoshida, T Kanemitsu, O Narabe, M Tobita
J New Remedies & Clinics 2009 58(8):143-155

Bibliography

Study snapshot

DesignRandomized, double-blind, placebo-controlled clinical trial
ModelWomen with dry skin
Samplen=42
InterventionFermentation-derived hyaluronic acid 120 mg/day, approximately 300 kDa, versus placebo
Duration6 weeks with post-treatment follow-up
EndpointsSkin moisture; Persistence after supplementation

What the study showed, in plain terms

This 2009 Japanese trial tested 120 mg/day of fermentation-derived HA in 42 women. Later peer-reviewed reviews report that skin moisture improved versus placebo from about two weeks and that part of the effect persisted after supplementation ended.

Key findings

What this study can and cannot tell us

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology