Tier 3 — preclinical

Coenzyme Q10 in the diet--daily intake and relative bioavailability

C Weber, A Bysted, G Hølmer
Molecular Aspects of Medicine 1997 18 Suppl:S251-254

Bibliography

PubMed
PMID 9266531
DOI
10.1016/S0098-2997(97)00003-4

Study snapshot

DesignDietary intake analysis plus randomized crossover human bioavailability study
ModelHealthy human participants and population dietary intake data
Sample
InterventionSingle 30 mg CoQ10 dose administered in a meal or as capsules
DurationSingle-dose crossover absorption assessment
EndpointsEstimated dietary CoQ10 intake; Serum CoQ10 concentration; Maximum serum CoQ10 concentration; Relative bioavailability from food versus capsules

What the study showed, in plain terms

The authors estimated average dietary CoQ10 intake at about 3–5 mg per day in a Danish diet, with meat and poultry providing most of it.

In a randomized crossover absorption experiment, a 30 mg dose of CoQ10 delivered in a meal significantly raised serum CoQ10 and produced a peak concentration that did not significantly differ from the capsule condition, showing that food-derived CoQ10 can be absorbed.

Key findings

Estimated average dietary CoQ10 intake was 3–5 mg/day, with about 64% coming from meat and poultry.

CoQ10 administered in a meal was absorbed to a significant degree in healthy participants.

Peak serum CoQ10 did not significantly differ between the tested meal and capsule delivery conditions for the 30 mg dose.

What this study can and cannot tell us

The food-intake estimate reflects a specific national diet from the 1990s and should not be treated as a universal current intake value.

The crossover study evaluated absorption after a single dose, not long-term clinical outcomes or disease treatment.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology