Tier 3 — preclinical
The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial
Medicine (Baltimore)
2021
100(5):e24252
Bibliography
- PubMed
- PMID 33592868
- PubMed Central
- PMC7870173
- Trial registry
- View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
- Funding
- Supported by Top Pharm & Medicalware, Taiwan; the company manufactured and provided the study product and placebo.
- Competing interests
- The authors declared no conflicts of interest.
Study snapshot
| Design | Randomized, double-blind, placebo-controlled clinical trial |
|---|---|
| Model | Adults with knee osteoarthritis and mild knee pain |
| Sample | n=47 |
| Intervention | Daily liquid containing low-MW HA 50 mg (50–500 kDa), glucosamine 750 mg and chondroitin 250 mg versus placebo |
| Duration | 8 weeks |
| Endpoints | WOMAC pain; WOMAC stiffness; WOMAC physical function; SF-36; Adverse events |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Citation network
Articles citing this research paper
Biohack Blueprint analyses that reference this study in their evidence base.
- Hyaluronic Acid vs Glucosamine for Joints: Which Has Better Evidence?Glucosamine has far more osteoarthritis research than oral HA, but guideline support is weak and average benefits are small. Oral HA is...Read analysis
- Hyaluronic Acid for Joints & Knee Pain: What Oral Evidence ShowsOral hyaluronic acid for joints and knee pain: direct trials, osteoarthritis evidence, studied doses and why oral supplements are not the same...Read analysis
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