Tier 3 — preclinical

Liquid combination of hyaluronan, glucosamine, and chondroitin as a dietary supplement for knee osteoarthritis patients with moderate knee pain: A randomized controlled study

Shyu-Jye Wang, Ya-Hui Wang, Liang-Chen Huang
Medicine (Baltimore) 2021 100(40):e27405

Bibliography

PubMed
PMID 34622845
PubMed Central
PMC8500584
DOI
10.1097/MD.0000000000027405

Study snapshot

DesignRandomized, double-blind, placebo-controlled clinical trial
ModelAdults with knee osteoarthritis and moderate knee pain
Samplen=80 modified intention-to-treat
InterventionDaily liquid containing HA 50 mg, glucosamine 750 mg and chondroitin 250 mg versus placebo
Duration8 weeks
EndpointsKOOS; WOMAC; SF-36; Pittsburgh Sleep Quality Index; Adverse events

What the study showed, in plain terms

This is a key negative study for balance. In adults with moderate knee pain, the same HA/glucosamine/chondroitin liquid formulation failed to significantly improve KOOS, WOMAC, SF-36 or sleep-quality outcomes compared with placebo after eight weeks. No treatment-related adverse events were reported.

Key findings

What this study can and cannot tell us

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology