Tier 3 — preclinical

A Review on Flavonoid Apigenin: Dietary Intake, ADME, Antimicrobial Effects, and Interactions with Human Gut Microbiota

Minqian Wang, Jenni Firrman, LinShu Liu, Kit Yam
BioMed Research International 2019 2019:7010467

Bibliography

PubMed
PMID 31737673
PubMed Central
PMC6817918

Study snapshot

DesignNarrative review
ModelPublished apigenin literature
Sample
Intervention
Duration
Endpoints

What the study showed, in plain terms

This review maps where apigenin comes from in the diet, how it is absorbed and metabolized, and how it may interact with gut microbes. It highlights apigenin's low water solubility and low oral bioavailability.

Key findings

Dietary apigenin intake varies widely. Much of the compound can reach the colon, where gut bacteria may transform apigenin or its glycosides into smaller metabolites. Laboratory studies also report antibacterial, antifungal and antiparasitic activity.

What this study can and cannot tell us

Most evidence summarized is preclinical or observational. Laboratory antimicrobial activity should not be interpreted as a proven clinical benefit.

Citation network

Articles citing this research paper

4 articles

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified