Tier 2 — strong
Sublingual NMN administration increases early circulating terminal catabolites 2PY and 4PY compared with oral administration in healthy adult men
Scientific Reports
2026
16(1):27464
Bibliography
- PubMed
- PMID 42304075
- PubMed Central
- PMC13534420
- Funding
- The study was conducted by investigators at Wellness Science Labs, Meiji Holdings Co., Ltd.
- Competing interests
- Jun Wakabayashi, Seiichiro Higashi and Masashi Morifuji are employees of Meiji Holdings Co., Ltd.
Study snapshot
| Design | Randomized two-period crossover comparative pharmacokinetic study. |
|---|---|
| Model | Healthy adult men. |
| Sample | 14 enrolled; one discontinued after the first intervention, with approximately 13 completing both periods for efficacy comparison. |
| Intervention | Single 250 mg β-NMN dose administered orally and sublingually in crossover periods separated by an 8-day washout. |
| Duration | Acute 60-minute pharmacokinetic sampling after each administration route; 8-day washout between periods. |
| Endpoints | Blood NMN; Nicotinamide; NAD+; 2PY; 4PY; Route-related tolerability |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
Citation network
Articles citing this research paper
Biohack Blueprint analyses that reference this study in their evidence base.
- NMN Reddit in 2026: 16 Common Claims Checked Against Human ResearchReddit is useful for spotting real NMN questions, but not for settling them. We fact-check common claims about energy, brands, TMG, liposomal...Read analysis
- NMN Human Trials: Published Clinical Evidence Mapped and ExplainedThis living evidence map separates independent NMN trials from post-hoc and secondary publications, covering safety, NAD+, insulin sensitivity, exercise, sleep, blood pressure,...Read analysis
- How and When to Take NMN: Morning, Night, Food, Fasting & SublingualHuman trials do not support one mandatory NMN timing ritual. This guide explains morning vs afternoon, food, fasting, split dosing, sublingual use,...Read analysis
- Liposomal NMN vs Capsules, Powder and Sublingual NMNLiposomal NMN is marketed as more bioavailable, but direct human superiority data are missing. We compare standard oral, sublingual, powder, microcrystalline and...Read analysis
- NMN vs NR: Two Head-to-Head Human Studies Compared (2026)The 2026 head-to-head trial found similar whole-blood NAD+ increases from 1,000 mg/day NMN and NR. We compare pathways, pharmacology, evidence, safety and...Read analysis
- NMN Dosage: Human Doses From 100 mg to 2,000 mg ExplainedHuman NMN studies span roughly 250 to 2,000 mg/day, but no trial has established a universal anti-aging dose. This guide maps doses...Read analysis
- NMN Supplement: What It Is, How It Works & What Human Research ShowsNMN is a direct NAD+ precursor with a growing human evidence base. This guide separates proven NAD+ effects from unproven anti-aging claims...Read analysis
Editorial review
Reviewed by the Biohack Blueprint research team
Last verified
