Tier 4 — mechanistic

Apigenin Prevents UVB-Induced Cyclooxygenase 2 Expression: Coupled mRNA Stabilization and Translational Inhibition

Xin Tong, Rukiyah T. Van Dross, Adnan Abu-Yousif, Aubrey R. Morrison, Jill C. Pelling
Molecular and Cellular Biology 2007 27(1):283-296

Bibliography

PubMed
PMID 17074806
PubMed Central
PMC1800648
DOI
10.1128/MCB.01282-06

Study snapshot

DesignIn vitro molecular-mechanism study
ModelMouse 308 keratinocytes exposed to UVB
Sample
InterventionApigenin after UVB irradiation
Duration
EndpointsCOX-2 protein; COX-2 mRNA stability; HuR localization; TIAR-mediated translation; PGE2

What the study showed, in plain terms

This mechanistic study examined how apigenin suppresses UVB-induced COX-2 in keratinocytes.

Key findings

Apigenin altered post-transcriptional regulation of COX-2, involving HuR-mediated mRNA stabilization together with TIAR-associated suppression of translation.

What this study can and cannot tell us

These are cell-culture mechanisms and do not establish clinical photoprotection or cancer prevention from oral apigenin.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology