Early treatment using betaine and methionine for a neonate with MTHFR deficiency

Eri Nishimoto, Yoko Ito, Takafumi Sakakibara, Toshiya Nishikubo
Pediatrics international : official journal of the Japan Pediatric Society 2019 61(12):1265-1266

Bibliography

PubMed
PMID 31782227
DOI
10.1111/ped.14018
Funding
Funding was not specified in the indexed record or accessible funding metadata.
Competing interests
A competing-interest declaration was not available in the indexed record or accessible disclosure metadata.

Study snapshot

DesignIndexed case report; abstract unavailable
ModelHuman participants
SampleNot available in the indexed record
InterventionFormulation and dose require the original full report
DurationNot available in the indexed record
EndpointsHistorical or clinical context

What the study showed, in plain terms

Published in 2019, this source examined prescription betaine and inherited metabolic disorders. It is retained for source traceability. Abstract unavailable in PubMed and no accessible full report was verified for this summary. The paper title is not treated as sufficient evidence of efficacy, dose, safety or causality.

The indexed record verifies the publication and citation, but supplies no abstract. A quantitative effect or complete treatment result is not established from this record alone.

Abstract unavailable in PubMed and no accessible full report was verified for this summary. The paper title is not treated as sufficient evidence of efficacy, dose, safety or causality.

Continue with TMG Data Center

Continue with TMG, Methylation and MTHFR: Understanding the Evidence

Key findings

  • The indexed record verifies the publication and citation, but supplies no abstract.
  • A quantitative effect or complete treatment result is not established from this record alone.
  • The recorded outcome domains were Historical or clinical context.

What this study can and cannot tell us

  • Abstract unavailable in PubMed and no accessible full report was verified for this summary. The paper title is not treated as sufficient evidence of efficacy, dose, safety or causality.
  • Source basis: Bibliographic data only; no abstract available. Missing method details, funding information or participant denominators are not inferred.

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Guidelines for the diagnosis and management of cystathionine beta-synthase deficiency
Andrew A M Morris et al. · Journal of inherited metabolic disease · 2017
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Postauthorization safety study of betaine anhydrous
Ulrike Mütze et al. · Journal of inherited metabolic disease · 2022
Tier 4
Cystathionine beta synthase deficiency and brain edema associated with methionine excess under betaine supplementation: Four new cases and a review of the evidence
Bernd C Schwahn et al. · JIMD reports · 2020
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Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial
Apolline Imbard et al. · Orphanet journal of rare diseases · 2022

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology