Tier 3 — preclinical

Chemical composition of low-molecular weight hyaluronic acid from comb (chicken) and maintaining the moisture effect of skin by a clinical test

Takao Terashita, Norifumi Shirasaka, Mizuho Kusuda, Sachio Wakayama
Memoirs of the Faculty of Agriculture of Kinki University 2011 44:1-8

Bibliography

Study snapshot

DesignRandomized, single-blind, placebo-controlled clinical trial within a compositional study
ModelAdults with skin-moisture assessment conducted in China
Samplen=107
Intervention280 mg/day low-molecular-weight chicken-comb preparation containing 13.4% HA, approximately 37.5 mg HA/day; major components about 1.5 and 5 kDa
Duration30 days
EndpointsSkin moisture; Skin pH

What the study showed, in plain terms

The clinical portion of this 2011 study randomized 107 participants to a low-molecular-weight chicken-comb preparation or placebo for 30 days. The active product supplied about 37.5 mg/day of HA and was reported to increase skin moisture and pH. Because it was single-blind and used a preparation rather than purified HA, it is supporting rather than high-tier efficacy evidence.

Key findings

What this study can and cannot tell us

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology