Tier 4 — mechanistic
Acute exposure of apigenin induces hepatotoxicity in Swiss mice
PLoS ONE
2012
7(2):e31964
Bibliography
- PubMed
- PMID 22359648
- PubMed Central
- PMC3281105
- Funding
- Research Support, Non-U.S. Government; specific funding details were not clearly available in the indexed record reviewed.
- Competing interests
- The authors declared that no competing interests existed.
Study snapshot
| Design | Acute dose-ranging animal toxicology study |
|---|---|
| Model | Swiss mice |
| Sample | Multiple control and dose groups; exact total N was not stated in the PubMed abstract. |
| Intervention | Intraperitoneal apigenin at 25, 50, 100 or 200 mg/kg |
| Duration | Acute exposure |
| Endpoints | ALT, AST and ALP; Liver histology; Reactive oxygen species; Lipid peroxidation; Glutathione redox state; Antioxidant enzyme activity; Liver gene-expression profile |
What the study showed, in plain terms
Key findings
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