Tier 1 — highest

A Systematic Review Supporting the Endocrine Society Clinical Practice Guidelines on Vitamin D

Vishal Paresh Shah, Tarek Nayfeh, Yahya Alsawaf, Samer Saadi, Magdoleen Farah, Ye Zhu, Mohammed Firwana, Mohamed Seisa, Zhen Wang, Robert Scragg, Mairead E Kiely, Paul Lips, Deborah M Mitchell, Marie B Demay, Anastassios G Pittas, Mohammad Hassan Murad
The Journal of clinical endocrinology and metabolism 2024 109(8):1961-1974

Bibliography

PubMed
PMID 38828942
DOI
10.1210/clinem/dgae312
Funding
Funding is not specified in the indexed abstract or accessible funding metadata. Consult the original publication for the declaration.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignSystematic evidence review supporting clinical practice guidance
ModelHuman evidence synthesis
Sample151 included studies addressing 14 clinical questions
InterventionVitamin D versus no vitamin D, dosing comparisons and testing strategies
DurationVaried across included studies
EndpointsPopulation-specific disease prevention; Dosing-related benefits and harms; Screening evidence

What the study showed, in plain terms

This publication examines population-specific disease prevention, dosing-related benefits and harms, screening evidence. Study population or evidence base: 151 included studies addressing 14 clinical questions. Intervention or exposure: Vitamin D versus no vitamin D, dosing comparisons and testing strategies.

Key findings

Benefits varied by population, with support for selected uses in older age and prediabetes. The review found no trials demonstrating benefits and harms of routine vitamin D screening.

What this study can and cannot tell us

Evidence certainty varied by question and many optimal-dose questions remained unresolved. This evidence review and its companion guideline are related publications, not separate trial populations.

Related papers in the corpus

Tier 2
Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline
Marie B Demay et al. · The Journal of clinical endocrinology and metabolism · 2024

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Biohack Blueprint Research