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Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline

Marie B Demay, Anastassios G Pittas, Daniel D Bikle, Dima L Diab, Mairead E Kiely, Marise Lazaretti-Castro, Paul Lips, Deborah M Mitchell, M Hassan Murad, Shelley Powers, Sudhaker D Rao, Robert Scragg, John A Tayek, Amy M Valent, Judith M E Walsh, Christopher R McCartney
The Journal of clinical endocrinology and metabolism 2024 109(8):1907-1947

Bibliography

PubMed
PMID 38828931
Funding
Support is recorded from The Endocrine Society. See the original publication for grant and material-support details.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignGRADE-based clinical practice guideline
ModelHuman evidence synthesis
SampleGuideline panel addressing 14 prioritized clinical questions
InterventionPopulation-specific vitamin D prevention recommendations
DurationNot a new intervention; evidence-based guidance published in 2024
EndpointsDisease prevention; Dosing approach; Vitamin D testing

What the study showed, in plain terms

This publication examines disease prevention, dosing approach, vitamin d testing. Study population or evidence base: Guideline panel addressing 14 prioritized clinical questions. Intervention or exposure: Population-specific vitamin D prevention recommendations.

Key findings

The guideline supports selected prevention uses while advising against routine above-reference-intake supplementation in otherwise healthy adults under 75. It favors daily over intermittent high-dose treatment when supplementation is indicated in older adults.

What this study can and cannot tell us

Recommendations concern prevention in people without established treatment or testing indications. They do not replace individualized management of diagnosed deficiency or other clinical conditions.

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