Tier 3 — preclinical

Clinical effects of hyaluronic acid diet for moisture content of dry skin

Toshihide Sato, Takeshi Yoshida, Tomoyuki Kanemitsu, Kazuya Yoshida, Mineo Hasegawa, Osamu Urushibata
Aesthetic Dermatology 2007 17(1):33-39

Bibliography

Study snapshot

DesignRandomized, double-blind, placebo-controlled clinical trial
ModelMiddle-aged and older women with dry skin
Samplen=39
InterventionOral hyaluronic acid 120 mg/day, approximately 800 kDa, versus placebo
Duration6 weeks
EndpointsSkin moisture content; Dry-skin condition

What the study showed, in plain terms

This Japanese placebo-controlled trial tested 120 mg/day oral HA for six weeks in 39 women with dry skin. Later reviews report higher skin moisture versus placebo at weeks three and six. It is retained as direct historical evidence but graded below newer, larger trials.

Key findings

What this study can and cannot tell us

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology