Tier 3 — preclinical

Clinical effects of hyaluronic acid diet for dry and rough skin

T Sato, W Sakamoto, W Odanaka, K Yoshida, O Urushibata
Aesthetic Dermatology 2002 12:109-120

Bibliography

Study snapshot

DesignRandomized, double-blind, placebo-controlled clinical trial
ModelAdults with dry or rough skin
Samplen=35
InterventionOral hyaluronic acid 120 mg/day versus placebo
Duration4 weeks
EndpointsSkin moisture; Dryness and roughness; Skin condition

What the study showed, in plain terms

This 2002 Japanese trial tested 120 mg/day oral HA for four weeks in 35 adults with dry or rough skin. It is included to preserve the early human dose evidence, but its small sample, older reporting and limited indexing keep it below the modern RCT tier.

Key findings

What this study can and cannot tell us

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology