Tier 3 — preclinical

Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis

M Ricci, G M Micheloni, M Berti, F Perusi, E Sambugaro, E Vecchini, B Magnan
Musculoskeletal Surgery 2017 101(1):45-49

Bibliography

PubMed
PMID 27681813
DOI
10.1007/s12306-016-0428-x

Study snapshot

DesignRandomized comparative clinical study
ModelAdults aged 40–70 with early knee osteoarthritis
Samplen=60
InterventionThree weekly intra-articular HA injections versus oral Syalox 300 Plus (HA 300 mg + Boswellia 100 mg) for 20 days then Syalox 150 (HA 150 mg) for 20 days
Duration40-day oral regimen; outcomes at 3 months
EndpointsAmerican Knee Society Score; VAS pain

What the study showed, in plain terms

Both injected-HA and oral-treatment groups improved knee scores and pain over three months. The oral regimen included Boswellia during its first 20 days and there was no placebo group, so the study supports feasibility of an oral HA-containing regimen rather than isolated HA efficacy.

Key findings

What this study can and cannot tell us

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology