Tier 1 — highest

Effects of Vitamin D Supplementation on Insulin Sensitivity and Secretion in Prediabetes

Neda Rasouli, Irwin G Brodsky, Ranee Chatterjee, Sun H Kim, Richard E Pratley, Myrlene A Staten, Anastassios G Pittas, D2d Research Group
The Journal of clinical endocrinology and metabolism 2022 107(1):230-240

Bibliography

PubMed
PMID 34473295
PubMed Central
PMC8684490
DOI
10.1210/clinem/dgab649
Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Support is recorded from NIDDK NIH HHS. See the original publication for grant and material-support details.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignPrespecified secondary analysis of the randomized D2d trial
ModelHuman participants
SampleAdults with prediabetes in the D2d metabolic analysis
InterventionVitamin D3 4,000 IU/day or placebo
Duration24 months
EndpointsDisposition index; Insulin sensitivity; C-peptide response

What the study showed, in plain terms

This publication examines disposition index, insulin sensitivity, c-peptide response. Study population or evidence base: Adults with prediabetes in the D2d metabolic analysis. Intervention or exposure: Vitamin D3 4,000 IU/day or placebo.

Key findings

The overall cohort showed no significant improvement in estimated beta-cell function or insulin-sensitivity measures. A severely vitamin D-deficient subgroup showed a favorable signal.

What this study can and cannot tell us

A secondary analysis with a subgroup finding. It does not establish overall metabolic benefit or replace the parent trial's diabetes-incidence result.

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