Tier 4 — mechanistic

Dietary quercetin intake is not associated with risk of metabolic dysfunction-associated steatotic liver disease in a general adult population

Juanjuan Liu, Hongmei Wu, Yeqing Gu, Ge Meng, Xuehui Wu, Dandan Zhu, Qing Zhang, Li Liu, Sizhen Lai, Yinxiao Chen, Dongli Wang, Shaomei Sun, Xing Wang, Qiyu Jia, Kun Song, Kaijun Niu
European journal of nutrition 2025 64(5):246

Bibliography

PubMed
PMID 40694145
DOI
10.1007/s00394-025-03764-0
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
Reported disclosure: Declarations. Conflict of interest: The authors declare no conflict of interest.

Study snapshot

DesignProspective observational dietary cohort
ModelHuman observational research
Sample16,746 adults; 3,544 incident MASLD cases
InterventionDietary quercetin intake estimated by food-frequency questionnaire
DurationAverage follow-up approximately 3.47 years
EndpointsSource-specific outcomes described in the key findings

What the study showed, in plain terms

Published in 2025, this source examined liver and metabolic health. Design: Prospective observational dietary cohort. Sample/model: 16,746 adults; 3,544 incident MASLD cases. The exposure or intervention was Dietary quercetin intake estimated by food-frequency questionnaire. Follow-up or treatment period: Average follow-up approximately 3.47 years.

Dietary quercetin was not associated with incident MASLD after multivariable adjustment.

Observational dietary estimates are subject to measurement error and confounding. This null association does not directly test concentrated supplements.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Weight Loss, Blood Sugar and Fatty Liver: Human Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Dietary quercetin was not associated with incident MASLD after multivariable adjustment.
  • The recorded outcome domains were Source-specific outcomes described in the key findings.
  • The exposure was observed rather than assigned as an isolated supplement treatment.

What this study can and cannot tell us

  • Observational dietary estimates are subject to measurement error and confounding. This null association does not directly test concentrated supplements.
  • Confounding, dietary patterns, illness, medication use and reverse causation can influence an association. Blood or dietary concentrations do not identify the effect of starting a capsule.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 1
Effects of Quercetin on Metabolic Dysfunction-Associated Steatotic Liver Disease: A Systematic Review and Meta-Analysis
Dachuan Jin et al. · Food science & nutrition · 2025

Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology