Tier 4 — mechanistic

Exploring the effects of Dasatinib, Quercetin, and Fisetin on DNA methylation clocks: a longitudinal study on senolytic interventions

Edwin Lee, Natàlia Carreras-Gallo, Leilani Lopez, Logan Turner, Aaron Lin, Tavis L Mendez, Hannah Went, Alan Tomusiak, Eric Verdin, Michael Corley, Lishomwa Ndhlovu, Ryan Smith, Varun B Dwaraka
Aging 2024 16(4):3088-3106

Bibliography

PubMed
PMID 38393697
PubMed Central
PMC10929829
DOI
10.18632/aging.205581
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
Reported disclosure: NC, VBD, RS, HW, AL, LT, and TLM are employees of TruDiagnostic.

Study snapshot

DesignUncontrolled longitudinal senolytic pilot with partially overlapping sequential cohorts
ModelHuman observational research
Sample19 received dasatinib plus quercetin; a later 19-person cohort included 10 returning participants
InterventionDasatinib plus quercetin, followed in a later study by a fisetin-containing regimen
Duration6 months per intervention; later cohort assessed after a year
EndpointsSenescence-related measurements

What the study showed, in plain terms

Published in 2024, this source examined senescence and longevity. Design: Uncontrolled longitudinal senolytic pilot with partially overlapping sequential cohorts. Sample/model: 19 received dasatinib plus quercetin; a later 19-person cohort included 10 returning participants. The exposure or intervention was Dasatinib plus quercetin, followed in a later study by a fisetin-containing regimen. Follow-up or treatment period: 6 months per intervention; later cohort assessed after a year.

Some first-generation and mitotic epigenetic clocks accelerated and telomere length decreased during D+Q; other clock generations did not significantly change.

No randomized concurrent comparator, overlapping participants, and multiple clocks. The later fisetin comparison does not establish reversal of aging or a protective causal effect.

Continue with Quercetin Data Center

For topic-level interpretation, read Is Quercetin a Senolytic? Human Evidence vs Longevity Claims. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Some first-generation and mitotic epigenetic clocks accelerated and telomere length decreased during D+Q; other clock generations did not significantly change.
  • The recorded outcome domains were Senescence-related measurements.
  • The exposure was observed rather than assigned as an isolated supplement treatment.

What this study can and cannot tell us

  • No randomized concurrent comparator, overlapping participants, and multiple clocks. The later fisetin comparison does not establish reversal of aging or a protective causal effect.
  • Confounding, dietary patterns, illness, medication use and reverse causation can influence an association. Blood or dietary concentrations do not identify the effect of starting a capsule.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology