Tier 2 — strong

The possible therapeutic role of curcumin and quercetin in the early-stage of COVID-19-Results from a pragmatic randomized clinical trial

Ikram Din Ujjan, Saeed Khan, Roohi Nigar, Hammad Ahmed, Sagheer Ahmad, Amjad Khan
Frontiers in nutrition 2022 9:1023997

Bibliography

PubMed
PMID 36742008
PubMed Central
PMC9889936
DOI
10.3389/fnut.2022.1023997
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
Reported disclosure: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Study snapshot

DesignRandomized open-label adjunctive pilot trial
ModelHuman intervention research
Sample50 COVID-19 outpatients; 25 per group
InterventionCurcumin 168 mg plus quercetin 260 mg/day added to usual care
Duration14 days; principal comparison after 7 days
EndpointsSymptoms and quality of life

What the study showed, in plain terms

Published in 2022, this source examined immunity and respiratory health. Design: Randomized open-label adjunctive pilot trial. Sample/model: 50 COVID-19 outpatients; 25 per group. The exposure or intervention was Curcumin 168 mg plus quercetin 260 mg/day added to usual care. Follow-up or treatment period: 14 days; principal comparison after 7 days.

Viral-test negativity favored the combination. The between-group symptom-resolution difference was not significant.

Small, unblinded combination trial. Quercetin-alone efficacy and effects on severe outcomes were not established.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Immune Health, Colds and COVID-19. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Viral-test negativity favored the combination.
  • The between-group symptom-resolution difference was not significant.
  • The recorded outcome domains were Symptoms and quality of life.
  • The result applies to the tested exposure: Curcumin 168 mg plus quercetin 260 mg/day added to usual care; 14 days; principal comparison after 7 days.

What this study can and cannot tell us

  • Small, unblinded combination trial. Quercetin-alone efficacy and effects on severe outcomes were not established.
  • Without a sufficiently blinded concurrent control, time effects, expectations, co-interventions and regression toward the mean can explain part of an apparent improvement.
  • Source basis: Source check: accessible full text and indexed metadata. Missing method details, funding information or participant denominators are not inferred.

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Immune Preconditioning with Oral Quercetin Supplement and COVID-19 mRNA Vaccine Responses: A Randomized, Double-Blind, Placebo-Controlled Trial
Shokichi Takahama et al. · The Journal of nutrition · 2026
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The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial
Mojtaba Shohan et al. · European journal of pharmacology · 2022
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Oral Co-Supplementation of Curcumin, Quercetin, and Vitamin D3 as an Adjuvant Therapy for Mild to Moderate Symptoms of COVID-19-Results From a Pilot Open-Label, Randomized Controlled Trial
Amjad Khan et al. · Frontiers in pharmacology · 2022

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology