Tier 2 — strong

Memory-Enhancing Effect of 8-Week Consumption of the Quercetin-Enriched Culinary Herbs-Derived Functional Ingredients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Jintanaporn Wattanathorn, Woraluck Somboonporn, Wipawee Thukham-Mee, Sudarat Sungkamnee
Foods (Basel, Switzerland) 2022 11(17):2678

Bibliography

PubMed
PMID 36076862
PubMed Central
PMC9455773
DOI
10.3390/foods11172678
Funding
Reported funding/support: Research Institute for High Human Performance and Health Promotion, Khon Kaen University, ThailandThis research was funded by the Research Institute for High Human Performance and Health Promotion, Khon Kaen University, Thailand.
Competing interests
Reported disclosure: The authors declare no conflict of interest.

Study snapshot

DesignRandomized double-blind placebo-controlled herbal trial
ModelHuman intervention research
Sample45 participants
InterventionCombined Polygonum odoratum and Morus alba functional ingredient at 50 or 1,500 mg/day
Duration8 weeks
EndpointsCognitive, mood, or sleep measures; Protein activity, binding or signaling

What the study showed, in plain terms

Published in 2022, this source examined brain, cognition and sleep. Design: Randomized double-blind placebo-controlled herbal trial. Sample/model: 45 participants. The exposure or intervention was Combined Polygonum odoratum and Morus alba functional ingredient at 50 or 1,500 mg/day. Follow-up or treatment period: 8 weeks.

The higher-dose herbal mixture improved working-memory measures and altered exploratory enzyme measures.

Whole-herb mixture rather than isolated quercetin. The ingredient's mass is not a quercetin dose.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Brain Fog, Memory and Sleep: Human Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The higher-dose herbal mixture improved working-memory measures and altered exploratory enzyme measures.
  • The recorded outcome domains were Cognitive, mood, or sleep measures; Protein activity, binding or signaling.
  • The result applies to the tested exposure: Combined Polygonum odoratum and Morus alba functional ingredient at 50 or 1,500 mg/day; 8 weeks.

What this study can and cannot tell us

  • Whole-herb mixture rather than isolated quercetin. The ingredient's mass is not a quercetin dose.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: accessible full text and indexed metadata. Missing method details, funding information or participant denominators are not inferred.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology