Tier 2 — strong

Oral Preparation of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin (Ialuril® Soft Gels) for the Prevention of LUTS after Intravesical Chemotherapy

Celeste Manfredi, Lorenzo Spirito, Francesco Paolo Calace, Raffaele Balsamo, Marco Terribile, Marco Stizzo, Lorenzo Romano, Luigi Napolitano, Gianluigi Califano, Luigi Cirillo, Giovanni Maria Fusco, Claudia Rosati, Carmelo Quattrone, Carmine Sciorio, Massimiliano Creta, Nicola Longo, Marco De Sio, Davide Arcaniolo
Pathophysiology : the official journal of the International Society for Pathophysiology 2022 29(3):365-373

Bibliography

PubMed
PMID 35893598
PubMed Central
PMC9326532
DOI
10.3390/pathophysiology29030028
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
Reported disclosure: The authors declare no conflict of interest.

Study snapshot

DesignRandomized double-blind placebo-controlled supportive-care pilot
ModelHuman intervention research
Sample34 patients undergoing intravesical chemotherapy for bladder cancer
InterventionHyaluronic acid, chondroitin, curcumin, and quercetin combination or placebo
DurationPeri-instillation schedules with follow-up through 13 months
EndpointsSymptoms and quality of life; Urinary or pelvic symptoms

What the study showed, in plain terms

Published in 2022, this source examined prostate and urinary health. Design: Randomized double-blind placebo-controlled supportive-care pilot. Sample/model: 34 patients undergoing intravesical chemotherapy for bladder cancer. The exposure or intervention was Hyaluronic acid, chondroitin, curcumin, and quercetin combination or placebo. Follow-up or treatment period: Peri-instillation schedules with follow-up through 13 months.

Urinary symptom scores and pain ratings favored the combination at selected follow-up visits.

Small multi-ingredient trial; benefit cannot be assigned to quercetin. This is supportive symptom research, not evidence of cancer treatment efficacy.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Prostatitis and Chronic Pelvic Pain. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Urinary symptom scores and pain ratings favored the combination at selected follow-up visits.
  • The recorded outcome domains were Symptoms and quality of life; Urinary or pelvic symptoms.
  • The result applies to the tested exposure: Hyaluronic acid, chondroitin, curcumin, and quercetin combination or placebo; Peri-instillation schedules with follow-up through 13 months.

What this study can and cannot tell us

  • Small multi-ingredient trial; benefit cannot be assigned to quercetin. This is supportive symptom research, not evidence of cancer treatment efficacy.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 2
Treatment of interstitial cystitis with a quercetin supplement
F Katske et al. · Techniques in urology · 2001
Tier 2
Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial
D A Shoskes et al. · Urology · 1999

Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology