Tier 4 — mechanistic

Quercetin topical application, from conventional dosage forms to nanodosage forms

T Hatahet, M Morille, A Hommoss, J M Devoisselle, R H Müller, S Bégu
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2016 108:41

Bibliography

PubMed
PMID 27565033
DOI
10.1016/j.ejpb.2016.08.011
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignNarrative review of topical quercetin and formulation design
ModelNarrative or mixed evidence review
SampleCell, animal, and skin-delivery literature; no new clinical cohort
InterventionConventional and experimental topical formulations
DurationApproximately 25 years of literature reviewed
EndpointsSource-specific outcomes described in the key findings

What the study showed, in plain terms

Published in 2016, this source examined skin and topical formulations. Its evidence base was Cell, animal, and skin-delivery literature; no new clinical cohort. It evaluated Conventional and experimental topical formulations across Approximately 25 years of literature reviewed.

Quercetin has experimental skin effects, but solubility and penetration complicate topical delivery.

Formulation and preclinical findings do not establish anti-aging or wound-healing efficacy of oral supplements or every topical product.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Skin and Hair: Oral vs Topical Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Quercetin has experimental skin effects, but solubility and penetration complicate topical delivery.
  • The recorded outcome domains were Source-specific outcomes described in the key findings.

What this study can and cannot tell us

  • Formulation and preclinical findings do not establish anti-aging or wound-healing efficacy of oral supplements or every topical product.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology