Tier 4 — mechanistic

Quercetin and Its Anti-Allergic Immune Response

Jiri Mlcek, Tunde Jurikova, Sona Skrovankova, Jiri Sochor
Molecules (Basel, Switzerland) 2016 21(5):623

Bibliography

PubMed
PMID 27187333
PubMed Central
PMC6273625
DOI
10.3390/molecules21050623
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
Reported disclosure: The authors declare no conflict of interest.

Study snapshot

DesignNarrative review of anti-allergic mechanisms
ModelNarrative or mixed evidence review
SampleLaboratory and limited clinical literature; no new trial cohort
InterventionQuercetin effects on mast cells and immune mediators
DurationLiterature available at publication
EndpointsInflammatory measures

What the study showed, in plain terms

Published in 2016, this source examined allergies, histamine and mast cells. Its evidence base was Laboratory and limited clinical literature; no new trial cohort. It evaluated Quercetin effects on mast cells and immune mediators across Literature available at publication.

The review describes inhibition of selected mast-cell and inflammatory pathways and possible anti-allergic applications.

Many broad therapeutic statements are based on preclinical evidence. It does not demonstrate prevention of anaphylaxis or clinical superiority to prescribed allergy medicines.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Allergies: Hay Fever Evidence and Limits. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The review describes inhibition of selected mast-cell and inflammatory pathways and possible anti-allergic applications.
  • The recorded outcome domains were Inflammatory measures.

What this study can and cannot tell us

  • Many broad therapeutic statements are based on preclinical evidence. It does not demonstrate prevention of anaphylaxis or clinical superiority to prescribed allergy medicines.
  • The conclusions inherit the limitations of the underlying studies. A narrative interpretation or guideline recommendation is not a new randomized treatment comparison.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review
Matteo Naso et al. · Nutrients · 2025

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