Tier 2 — strong

Comparative evaluation of the effect of permeation enhancers, lipid nanoparticles and colloidal silica on in vivo human skin penetration of quercetin

S Scalia, E Franceschinis, D Bertelli, V Iannuccelli
Skin pharmacology and physiology 2013 26(2):57

Bibliography

PubMed
PMID 23207877
DOI
10.1159/000345210
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignComparative in vivo human skin penetration study
ModelHuman intervention research
SampleHuman volunteers; sample size not stated in the indexed abstract
InterventionTopical quercetin formulations with penetration enhancers, lipid nanoparticles, or 2% colloidal silica
DurationShort-term topical application and tape stripping
EndpointsSource-specific outcomes described in the key findings

What the study showed, in plain terms

Published in 2013, this source examined skin and topical formulations. Design: Comparative in vivo human skin penetration study. Sample/model: Human volunteers; sample size not stated in the indexed abstract. The exposure or intervention was Topical quercetin formulations with penetration enhancers, lipid nanoparticles, or 2% colloidal silica. Follow-up or treatment period: Short-term topical application and tape stripping.

Colloidal silica increased quercetin uptake into skin; other tested formulation changes did not show significant improvements.

Measures local skin delivery rather than oral absorption or clinical skin benefit. Sample size and formulation details require full-method confirmation.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Skin and Hair: Oral vs Topical Evidence. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Colloidal silica increased quercetin uptake into skin; other tested formulation changes did not show significant improvements.
  • The recorded outcome domains were Source-specific outcomes described in the key findings.
  • The result applies to the tested exposure: Topical quercetin formulations with penetration enhancers, lipid nanoparticles, or 2% colloidal silica; Short-term topical application and tape stripping.

What this study can and cannot tell us

  • Measures local skin delivery rather than oral absorption or clinical skin benefit. Sample size and formulation details require full-method confirmation.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Citation network

Articles citing this research paper

1 article

Biohack Blueprint analyses that reference this study in their evidence base.

Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology