Tier 2 — strong

Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis

Hiroaki Matsuno, Hiroshi Nakamura, Kou Katayama, Seigaku Hayashi, Syogo Kano, Kazuo Yudoh, Yoshinobu Kiso
Bioscience, biotechnology, and biochemistry 2009 73(2):288

Bibliography

PubMed
PMID 19202302
DOI
10.1271/bbb.80418
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignUncontrolled joint-supplement intervention
ModelHuman intervention research
Sample46 patients with osteoarthritis and 22 with rheumatoid arthritis
InterventionGlucosamine, chondroitin, and quercetin-glucoside combination
Duration3 months
EndpointsSymptoms and quality of life

What the study showed, in plain terms

Published in 2009, this source examined bone and joint health. Design: Uncontrolled joint-supplement intervention. Sample/model: 46 patients with osteoarthritis and 22 with rheumatoid arthritis. The exposure or intervention was Glucosamine, chondroitin, and quercetin-glucoside combination. Follow-up or treatment period: 3 months.

Osteoarthritis symptoms and selected synovial-fluid measures improved; comparable changes were not seen in rheumatoid arthritis.

No placebo comparison described and three active ingredients. It does not establish quercetin-only efficacy, disease modification, or treatment of rheumatoid arthritis.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin for Inflammation: CRP, Pain and Human Trials. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • Osteoarthritis symptoms and selected synovial-fluid measures improved; comparable changes were not seen in rheumatoid arthritis.
  • The recorded outcome domains were Symptoms and quality of life.
  • The result applies to the tested exposure: Glucosamine, chondroitin, and quercetin-glucoside combination; 3 months.

What this study can and cannot tell us

  • No placebo comparison described and three active ingredients. It does not establish quercetin-only efficacy, disease modification, or treatment of rheumatoid arthritis.
  • Without a sufficiently blinded concurrent control, time effects, expectations, co-interventions and regression toward the mean can explain part of an apparent improvement.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

Related papers in the corpus

Tier 2
Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study
Noriyuki Kanzaki et al. · Journal of the science of food and agriculture · 2012

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology