Tier 2 — strong

Ingestion of onion soup high in quercetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in man: a pilot study

Gary P Hubbard, Siegfried Wolffram, Ric de Vos, Arnaud Bovy, Jonathan M Gibbins, Julie A Lovegrove
The British journal of nutrition 2006 96(3):482

Bibliography

PubMed
PMID 16925853
Funding
Funding was not specified in the indexed record or the disclosure metadata available for this entry.
Competing interests
A competing-interest declaration was not available in the indexed record or the disclosure metadata used for this entry.

Study snapshot

DesignDouble-blind randomized crossover dietary platelet pilot
ModelHuman intervention research
SampleHuman volunteers; sample size not stated in the indexed abstract
InterventionOnion soup containing 69 mg versus 5 mg total quercetin
DurationAcute meal comparisons
EndpointsPlatelet or coagulation measurements; Protein activity, binding or signaling

What the study showed, in plain terms

Published in 2006, this source examined safety, interactions and special populations. Design: Double-blind randomized crossover dietary platelet pilot. Sample/model: Human volunteers; sample size not stated in the indexed abstract. The exposure or intervention was Onion soup containing 69 mg versus 5 mg total quercetin. Follow-up or treatment period: Acute meal comparisons.

The high-quercetin soup reduced selected collagen-stimulated platelet aggregation and signaling responses ex vivo.

Food-based laboratory platelet endpoints do not establish fewer thrombotic events, a quantified bleeding risk, or a safe antiplatelet substitution.

Continue with Quercetin Data Center

For topic-level interpretation, read Quercetin Side Effects and Safety: A Practical Guide. This is a related guide; the citation panel separately identifies articles that directly cite this paper.

Key findings

  • The high-quercetin soup reduced selected collagen-stimulated platelet aggregation and signaling responses ex vivo.
  • The recorded outcome domains were Platelet or coagulation measurements; Protein activity, binding or signaling.
  • The result applies to the tested exposure: Onion soup containing 69 mg versus 5 mg total quercetin; Acute meal comparisons.

What this study can and cannot tell us

  • Food-based laboratory platelet endpoints do not establish fewer thrombotic events, a quantified bleeding risk, or a safe antiplatelet substitution.
  • An individual controlled trial must be interpreted alongside its comparator, sample size, endpoint selection and independent replication. It does not validate a different commercial formulation or a general longevity claim.
  • Source basis: Source check: PubMed abstract and indexed metadata; full methods were not independently confirmed for this entry. Missing method details, funding information or participant denominators are not inferred.

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Editorial review

Reviewed by the Biohack Blueprint research team

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology