Tier 1 — highest

Vitamin D and Risk for Type 2 Diabetes in People With Prediabetes : A Systematic Review and Meta-analysis of Individual Participant Data From 3 Randomized Clinical Trials

Anastassios G Pittas, Tetsuya Kawahara, Rolf Jorde, Bess Dawson-Hughes, Ellen M Vickery, Edith Angellotti, Jason Nelson, Thomas A Trikalinos, Ethan M Balk
Annals of internal medicine 2023 176(3):355-363

Bibliography

PubMed
PMID 36745886
DOI
10.7326/M22-3018
Funding
Funding or support is described in the linked original publication; the indexed record does not provide a concise sponsor attribution.
Competing interests
A competing-interest declaration is not available in the indexed abstract or accessible disclosure metadata.

Study snapshot

DesignSystematic review and meta-analysis
ModelHuman evidence synthesis
SampleIndividual-participant data from 3 randomized prediabetes trials
InterventionDaily or weekly D3, or an active vitamin D analogue, versus placebo
DurationTrial-specific; 3-year absolute risk estimates
EndpointsProgression to diabetes; Regression to normal glucose regulation; Adverse events

What the study showed, in plain terms

This publication examines progression to diabetes, regression to normal glucose regulation, adverse events. Study population or evidence base: Individual-participant data from 3 randomized prediabetes trials. Intervention or exposure: Daily or weekly D3, or an active vitamin D analogue, versus placebo.

Key findings

The pooled adjusted analysis found a modest reduction in diabetes progression and more regression to normal glucose regulation in adults with prediabetes.

What this study can and cannot tell us

The evidence is specific to prediabetes and includes differing vitamin D interventions. Achieved blood-level analyses were not randomized dose comparisons and cannot establish an optimal target level.

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