Tier 3 — preclinical

Evaluation of the combined treatment of oral viscosupplementation with hyaluronic acid intra-articular injection on symptomatic knee osteoarthritis

E Panuccio, A Memeo, S Richetta
La Clinica Terapeutica 2015 166(5):e321-e326

Bibliography

PubMed
PMID 26550817
DOI
10.7417/T.2015.1886

Study snapshot

DesignRandomized, double-blind, placebo-controlled adjunct study
ModelAdults with symptomatic knee osteoarthritis after intra-articular HA injection
Samplen=100
InterventionAll participants received intra-articular HA; then randomized to an oral multi-ingredient HA/chondroitin/collagen/MSM/mineral formulation or placebo
Duration3 months
EndpointsVAS pain; KOOS; Tegner Lysholm score; Lequesne Index; Analgesic/NSAID use

What the study showed, in plain terms

After an intra-articular HA injection, 100 patients were randomized to an oral HA-containing multi-ingredient formulation or placebo. The combination arm showed favorable trends, particularly for pain and analgesic use, but the design cannot separate oral HA from the other ingredients or the background injection.

Key findings

What this study can and cannot tell us

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology