Tier 3 — preclinical

Effect of an oral preparation containing hyaluronic acid, chondroitin sulfate, hydrolyzed collagen type II and hydrolyzed keratin on synovial fluid features and clinical indices in knee osteoarthritis. A pilot study

F Oliviero, R Ramonda, A Hoxha, A Scanu, P Galozzi, M Favero, P Frallonardo, L Punzi
Reumatismo 2020 72(3):125-130

Bibliography

PubMed
PMID 33213125
DOI
10.4081/reumatismo.2020.1272

Study snapshot

DesignRandomized controlled pilot study
ModelAdults with knee OA and joint effusion undergoing arthrocentesis
Samplen=30
InterventionOral preparation with HA 120 mg, chondroitin sulfate 240 mg and hydrolyzed keratin 300 mg daily versus arthrocentesis-only control
Duration4 weeks
EndpointsWOMAC; Lequesne Index; VAS pain; Synovial-fluid cytokines

What the study showed, in plain terms

The combination-supplement group improved WOMAC, Lequesne and pain scores and showed changes in several synovial-fluid cytokines, whereas the control group did not. The sample was tiny and the product contained several active joint ingredients, so it does not isolate HA.

Key findings

What this study can and cannot tell us

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology