Tier 3 — preclinical

Oral hyaluronan relieves knee pain: a review

Mariko Oe, Toshiyuki Tashiro, Hideto Yoshida, Hiroshi Nishiyama, Yasunobu Masuda, Koh Maruyama, Takashi Koikeda, Reiko Maruya, Naoshi Fukui
Nutrition Journal 2016 15:11

Bibliography

PubMed
PMID 26818459
PubMed Central
PMC4729158
DOI
10.1186/s12937-016-0128-2
Competing interests
Several authors were employees of Kewpie Corporation R&D.

Study snapshot

DesignNarrative review
ModelClinical trials of oral hyaluronan for knee pain and osteoarthritis plus mechanistic studies
SampleMultiple clinical trials reviewed
InterventionOral hyaluronan and HA-containing products across multiple doses and formulations
DurationVaried across reviewed studies
EndpointsKnee pain; Synovial effusion; Inflammation; Muscle strength; Mechanisms of intestinal HA signaling; Safety

What the study showed, in plain terms

This 2016 narrative review summarizes early randomized trials of oral hyaluronan for knee pain and osteoarthritis and discusses proposed intestinal and anti-inflammatory mechanisms.

It is valuable for locating older trials and understanding formulation history, but it is not a systematic review and several authors were Kewpie researchers.

The Data Center therefore uses it as background evidence, while relying on individual RCTs and the newer 2024 systematic review for efficacy judgments.

Key findings

What this study can and cannot tell us

  • Narrative rather than systematic methodology.
  • Industry-affiliated authors.
  • The review includes several mixed or proprietary HA-containing formulations.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology