Tier 3 — preclinical
Liposome-based loading enhances the distribution of nicotinamide riboside chloride into the brain and its neuroprotective effects in cerebral ischemic mice
Journal of Neurorestoratology
2024
12; 2; 100111
Bibliography
- Funding
- The complete funding declaration was not verified from the accessible publisher abstract.
- Competing interests
- The complete competing-interest declaration was not verified from the accessible publisher abstract.
Study snapshot
| Design | Intravenous pharmacokinetic, distribution and cerebral-ischemia experiments |
|---|---|
| Model | Healthy and cerebral-ischemia mice |
| Sample | Multiple mouse experiments; no human participants |
| Intervention | Liposomal NR chloride versus conventional NR chloride solution, administered by intravenous bolus |
| Duration | Acute pharmacokinetics and model-specific follow-up |
| Endpoints | Plasma exposure; Brain distribution; Infarct and behavioral measures |
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