Tier 2 — strong
Nicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial
JAMA
2026
Bibliography
- PubMed
- PMID 42848371
- Funding
- Funding details are not specified in the accessible publication information.
- Competing interests
- Disclosures include pharmaceutical fees and research support, and NR-related patents held by investigators. Individual declarations are detailed in the publication.
Study snapshot
| Design | Multicenter double-blind randomized placebo-controlled phase III trial |
|---|---|
| Model | Human participants |
| Sample | 410 randomized; 393 in the primary analysis |
| Intervention | NR 500 mg twice daily versus placebo |
| Duration | 52 weeks |
| Endpoints | MDS-UPDRS I–III; nonmotor symptoms; adverse events |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
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