Tier 2 — strong

Nicotinamide riboside combined with exercise to treat hypertension in middle-aged and older adults: a pilot randomized clinical trial

Lin Y, Zeidan RS, Lapierre-Nguyen S, Costello HM, Anton SD, Buford TW, Christou DD, Gumz ML, Leeuwenburgh C, Martens CR, McDermott MM, Migaud ME, Sandesara B, Seals DR, Qiu P, Wang Y, Mankowski RT
GeroScience 2025 47; 6; 6895-6908

Bibliography

PubMed
PMID 40770531
PubMed Central
PMC12638573
DOI
10.1007/s11357-025-01815-2
Funding
NIH National Institute on Aging grants R21AG064282, T32AG062728 and U01AG089107 supported the trial or contributing investigators.
Competing interests
The authors reported no competing interests.

Study snapshot

DesignRandomized placebo-controlled human trial
ModelHuman participants
Sample54 randomized; 49 completed; age 55 years or older
InterventionNR 1000 mg/day plus walking exercise, placebo plus exercise, or NR alone
Duration6 weeks
EndpointsDaytime systolic blood pressure; pulse-wave velocity; nighttime pressure

What the study showed, in plain terms

NR plus exercise was not superior to placebo plus exercise for the primary daytime systolic-blood-pressure outcome.

Key findings

NR plus exercise was not superior to placebo plus exercise for the primary daytime systolic-blood-pressure outcome.

What this study can and cannot tell us

Post hoc nighttime-pressure signals in participants not taking antihypertensives are hypothesis-generating, not proof that NR treats hypertension.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology