Tier 4 — mechanistic

New Crystalline Salts of Nicotinamide Riboside as Food Additives

Schabert G, Haase R, Parris J, Pala L, Hery-Barranco A, Spingler B, Spitz U
Molecules (Basel, Switzerland) 2021 26; 9; 2729

Bibliography

PubMed
PMID 34066468
PubMed Central
PMC8125264
DOI
10.3390/molecules26092729
Funding
University of Zurich and the Swiss National Science Foundation R’Equip programme, project 206021_164018.
Competing interests
Several authors were employees of Biosynth-Carbosynth, which sells NR derivatives; another was a former employee.

Study snapshot

DesignChemical synthesis, crystallography, solubility and stability experiments
ModelCrystalline NR hydrogen malate and hydrogen tartrate salts
SampleChemical samples; no human participants
InterventionPreparation and characterization of several stereoisomeric NR salts
DurationLaboratory synthesis and stability experiments
EndpointsSynthesis yield; Crystal structure; Purity; Stability

What the study showed, in plain terms

The study describes scalable preparation and characterization of crystalline NR hydrogen malate and hydrogen tartrate salts.

Key findings

The work establishes chemical structures and manufacturing/stability properties. Statements about nutritional promise should be distinguished from direct human comparative efficacy.

What this study can and cannot tell us

No human supplementation trial or clinical outcome comparison is reported. Chemical similarity does not prove equivalent performance of every finished retail product.

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Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology