Tier 3 — preclinical

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation

Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J
Science translational medicine 2016 8; 361; 361ra139

Bibliography

PubMed
PMID 27798264
PubMed Central
PMC5535761
DOI
10.1126/scitranslmed.aaf5504
Funding
Indexed grant support includes NIA NIH HHS, NIAMS NIH HHS. The complete funding declaration is not specified in the accessible abstract.
Competing interests
A complete competing-interest declaration is not specified in the accessible publication information.

Study snapshot

DesignPreclinical animal study with supporting assays as applicable
ModelMice, C. elegans and human transcript datasets
SampleMouse and worm muscular-dystrophy models; supporting human transcript data
InterventionDietary NR and NAD+ pathway analysis
DurationModel-specific disease experiments
EndpointsModel-specific physiological outcomes; Biochemical or functional measures reported in the study

What the study showed, in plain terms

NR improved selected muscle and cardiac pathology in experimental muscular dystrophy, alongside changes in PARylation and inflammation.

Key findings

NR improved selected muscle and cardiac pathology in experimental muscular dystrophy, alongside changes in PARylation and inflammation.

What this study can and cannot tell us

Human transcript signatures are observational. The treatment findings are preclinical and cannot establish efficacy in patients with muscular dystrophy.

Related papers in the corpus

Tier 3
Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle
Frederick DW et al. · Cell metabolism · 2016

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology