Tier 2 — strong
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans
Nature communications
2016
7; 12948
Bibliography
- PubMed
- PMID 27721479
- PubMed Central
- PMC5062546
- Funding
- ChromaDex sponsored the clinical study and supplied NR; additional research support is described in the paper.
- Competing interests
- Disclosures include ChromaDex employment, equity, research, advisory and consulting relationships, supplement-business interests and NAAD biomarker intellectual property.
Study snapshot
| Design | Human crossover pharmacokinetic study with supporting mouse experiments |
|---|---|
| Model | Human participants |
| Sample | One-person pilot plus 12-person crossover PK study; separate mouse experiments |
| Intervention | Single oral NR doses of 100, 300 and 1000 mg |
| Duration | Acute dose-response and time-course experiments |
| Endpoints | Blood NAD+ metabolome; NAAD; dose and time response |
What the study showed, in plain terms
Key findings
What this study can and cannot tell us
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