Tier 4 — mechanistic

Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk

Trammell SA, Trammell SA, Yu L, Redpath P, Migaud ME, Brenner C
The Journal of nutrition 2016 146; 5; 957-963

Bibliography

PubMed
PMID 27052539
PubMed Central
PMC6879052
DOI
10.3945/jn.116.230078
Funding
Complete funding details were not verified from the accessible abstract.
Competing interests
Complete competing-interest details were not verified from the accessible abstract.

Study snapshot

DesignAnalytical quantification using LC-MS/MS, isotope dilution and NMR
ModelRaw and commercially available cow milk
SampleMilk samples from individual cows and commercial products; no supplementation trial
InterventionMeasurement of NAD-related vitamins and NR stability in milk
DurationLaboratory analytical study
EndpointsNR and nicotinamide concentrations; NR stability; Protein association

What the study showed, in plain terms

The investigators identified NR as a substantial fraction of measured NAD precursor vitamins in cow milk, while absolute dietary quantities remained small relative to common supplement amounts.

Key findings

The abstract reports approximately 12 micromoles/L of measured precursor vitamins, around 40% as NR. Concentrations varied with sample and milk characteristics.

What this study can and cannot tell us

These are food-composition measurements, not evidence that a milk intake prevents aging or reproduces a supplement trial. Sample-specific values should not be treated as universal dietary guarantees.

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Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology