Tier 3 — preclinical

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

Cantó C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, Fernandez-Marcos PJ, Yamamoto H, Andreux PA, Cettour-Rose P, Gademann K, Rinsch C, Schoonjans K, Sauve AA, Auwerx J
Cell metabolism 2012 15; 6; 838-847

Bibliography

PubMed
PMID 22682224
PubMed Central
PMC3616313
Funding
Indexed grant support includes European Research Council. The complete funding declaration is not specified in the accessible abstract.
Competing interests
A complete competing-interest declaration is not specified in the accessible publication information.

Study snapshot

DesignPreclinical animal study with supporting assays as applicable
ModelMice and mammalian cells
SampleMouse and mammalian-cell experiments; group sizes vary
InterventionNR supplementation in cells and high-fat-diet mouse models
DurationExperimental feeding and laboratory protocols
EndpointsModel-specific physiological outcomes; Biochemical or functional measures reported in the study

What the study showed, in plain terms

NR increased NAD+ and sirtuin-related activity and improved selected metabolic outcomes in high-fat-diet mice.

Key findings

NR increased NAD+ and sirtuin-related activity and improved selected metabolic outcomes in high-fat-diet mice.

What this study can and cannot tell us

Mouse protection from diet-induced metabolic dysfunction does not override null outcomes in later human insulin-resistance trials.

Editorial review

Reviewed by the Biohack Blueprint research team

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