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Effect of parsley (Petroselinum crispum) intake on urinary apigenin excretion, blood antioxidant enzymes and biomarkers for oxidative stress in human subjects

S. E. Nielsen, J. F. Young, B. Daneshvar, S. T. Lauridsen, P. Knuthsen, B. Sandström, L. O. Dragsted
British Journal of Nutrition 1999 81(6):447-455

Bibliography

PubMed
PMID 10615220

Study snapshot

DesignRandomized crossover controlled feeding trial
Model14 healthy adults, 7 men and 7 women
Samplen = 14
InterventionControlled low-flavone diet with or without parsley providing 3.73-4.49 mg apigenin/MJ
DurationTwo-week crossover intervention
EndpointsUrinary apigenin excretion; Erythrocyte glutathione reductase; Superoxide dismutase; Catalase; Glutathione peroxidase; Protein oxidation biomarker

What the study showed, in plain terms

This randomized crossover feeding study tested whether adding apigenin-rich parsley to a controlled diet changes apigenin excretion and oxidative-stress biomarkers in humans.

Key findings

Parsley increased urinary apigenin and increased erythrocyte glutathione reductase and superoxide dismutase activities, while several other oxidative-stress measures did not significantly change.

What this study can and cannot tell us

The trial was small and short and tested parsley rather than isolated apigenin. Enzyme biomarkers do not establish a health outcome.

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