Tier 4 — mechanistic

Apigenin Inhibits UVB-Induced Skin Carcinogenesis: The Role of Thrombospondin-1 as an Anti-Inflammatory Factor

Salida Mirzoeva, Xin Tong, Bryan B. Bridgeman, Michael P. Plebanek, Olga V. Volpert
Neoplasia 2018 20(9):930-942

Bibliography

PubMed
PMID 30118999
PubMed Central
PMC6098219
DOI
10.1016/j.neo.2018.07.005

Study snapshot

DesignIn vivo mouse carcinogenesis study
ModelWild-type and thrombospondin-1 knockout SKH-1 hairless mice
Sample
InterventionTopical apigenin during UVB exposure
Duration
EndpointsSkin tumor development; TSP1 dependence; Inflammatory infiltrates; IL-6 and IL-12; Myeloid progenitor populations

What the study showed, in plain terms

This study tested whether thrombospondin-1 is required for apigenin's apparent protection against UVB-driven skin carcinogenesis in mice.

Key findings

Topical apigenin inhibited UVB-induced carcinogenesis in wild-type mice but not TSP1-knockout mice, supporting TSP1 as an important mediator.

What this study can and cannot tell us

The study uses topical exposure and a mouse model. It does not support claims that oral apigenin supplements prevent human skin cancer.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology