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Bioavailability of apigenin from apiin-rich parsley in humans

Hellen Meyer, Adrian Bolarinwa, Guenther Wolfram, Jakob Linseisen
Annals of Nutrition and Metabolism 2006 50(3):167-172

Bibliography

PubMed
PMID 16407641

Study snapshot

DesignHuman single-dose bioavailability study
Model11 healthy adults, 5 women and 6 men
Samplen = 11
InterventionSingle oral bolus of blanched parsley providing 65.8 ± 15.5 μmol apigenin per kg body weight
Duration28-hour plasma sampling with 24-hour urine collection
EndpointsPlasma apigenin concentration; Time to peak concentration; Urinary apigenin recovery; Red-blood-cell apigenin

What the study showed, in plain terms

Eleven healthy adults consumed apiin-rich parsley so researchers could measure how much dietary apigenin reached the circulation and urine.

Key findings

Average peak plasma apigenin was reached after about 7.2 hours, and only about 0.22% of the ingested dose was recovered in 24-hour urine, indicating limited systemic availability from this food source.

What this study can and cannot tell us

The study was small, used a single parsley exposure and did not measure clinical outcomes. Food-derived apiin is not identical to isolated apigenin supplements.

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