Tier 4 — mechanistic

Enhancing Recovery Through a Combined Mechanobiologic Intervention Following Meniscus Repair

University of Kentucky study team
ClinicalTrials.gov trial registry record 2022

Bibliography

Trial registry
View on ClinicalTrials.gov Registered trial — results not yet published in a peer-reviewed journal.
Funding
Academic study; public 2026 sources list the trial as withdrawn.
Competing interests
Not reported in the registry record.

Study snapshot

DesignPlanned Phase 2/3 randomized trial combining fisetin with a rehabilitation/biofeedback intervention.
ModelAdults aged 18-45 years following meniscus repair.
Sample0 actual participants; approximately 38 were planned.
InterventionPlanned fisetin approximately 20 mg/kg/day for two consecutive days, repeated after 28 days, beginning around eight weeks after surgery, within a combined mechanobiologic rehabilitation program.
DurationPlanned clinical and cartilage-related follow-up up to one year.
EndpointsIKDC knee score; Recovery after meniscus repair; Cartilage-related outcomes; Functional outcomes

What the study showed, in plain terms

This study planned to test intermittent fisetin as one part of a combined recovery strategy after meniscus repair.

The trial was withdrawn before enrolling participants. It contributes no evidence that fisetin improves meniscus healing, rehabilitation or cartilage outcomes.

Key findings

  • No participants were enrolled.
  • The planned fisetin regimen used two-day pulses separated by about one month.
  • Fisetin was embedded in a broader mechanobiologic intervention.

What this study can and cannot tell us

  • Withdrawn before enrollment.
  • No efficacy or safety outcomes.
  • Combination design would have complicated fisetin-specific attribution.

Editorial review

Reviewed by the Biohack Blueprint research team

Last verified

Dr. Khaled Mahmoud, MBBChCritical Care Medicine, Longevity Science & Editorial Direction Dr. Amr Yasser, PhDCardiometabolic, Musculoskeletal, Gut & Bioavailability Dr. Abdulla Mostafa, PhDCellular Senescence, Neurological, Mitochondrial & Brain-Ageing Biology