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Clinical evidence for low-molecular-weight collagen peptides in tendon and ligament tears: a systematic review with narrative synthesis
Frontiers in Medicine
2026
13:1891011
Bibliography
- PubMed
- PMID 42666580
- PubMed Central
- PMC13523136
- Funding
- The authors declared that no financial support was received for the work and/or its publication.
- Competing interests
- Luca Latini was employed by Centro Medico e Fisioterapia 'Salute e Benessere' and Nicolò Vitale by Centro Medicina Riabilitativa 'CMR'; remaining authors declared no commercial or financial relationships that could be construed as conflicts.
Study snapshot
| Design | Systematic review with narrative synthesis using PubMed and Scopus searches through 17 March 2026 |
|---|---|
| Model | Human tendon or ligament tears, postoperative repair/reconstruction, and closely related tendon/ligament conditions |
| Sample | 6 studies included |
| Intervention | Oral or injectable hydrolyzed/low-molecular-weight collagen peptide preparations; several oral interventions were multicomponent and formulations/routes varied substantially. |
| Duration | Review search through 17 March 2026; included-study follow-up varied |
| Endpoints | Pain; Function; Analgesic use; Imaging outcomes; Structural healing; Reinjury/return-to-sport evidence |
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